Abstract

Osteoblastic lesions pose a significant challenge in clinical practice, characterized by excessive bone formation leading to structural abnormalities and functional impairment. Effective management of these lesions requires a comprehensive approach that encompasses both pharmacological and surgical interventions. This article provides an overview of the therapeutic options available for osteoblastic lesions, ranging from pharmacological agents targeting bone metabolism to surgical procedures aimed at lesion removal and bone reconstruction. The pharmacological armamentarium includes bisphosphonates, denosumab, calcitonin, systemic chemotherapy, and hormonal therapy, which aim to inhibit bone resorption and control underlying pathology. Surgical interventions such as curettage, radiofrequency ablation, percutaneous cementoplasty, and resection with reconstruction are employed to remove the lesion, stabilize fractures, and restore skeletal function. Through a combination of pharmacological and surgical modalities, clinicians can effectively manage osteoblastic lesions and improve patient outcomes