Abstract

Depression is quite possibly of the most widely recognized mental problem, which causes global burden. Antidepressants and psychotherapies are the mainstay of treatment for despair, which have restrained efficacy. Accordingly, alternative procedures for stopping and treating melancholy are urgently required. Current scientific trials and preclinical researches have clarified that peripheral facial injection of botulinum neurotoxin type A (BoNT/A) is a speedy, effective and relative secure remedy for improving some signs of depression

Keywords: Depression, Botulinum neurotoxin, Hippocampus, Brain-derived neurotrophic factor, 5-HT