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Hindi Research Article
The Study of Analgesic Activity of Complexes of Magnesium Sulfate with Aspirin, Paracetamol and Naproxen
| Sangita Paul Kundu1, Md. Zakir Sultan2, Asma Rahman2, Sagar Kumar Paul3, Satabdi Shikder3, Shampa Kundu4, Md. Shah Amran1* and Md.Amjad Hossain1 | |
| 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh | |
| 2Centre for Advanced Research in Sciences, University of Dhaka, Dhaka-1000, Bangladesh | |
| 3Department of Pharmacy, State University of Bangladesh, Dhanmondhi, Dhaka-1205, Bangladesh | |
| 4Department of Pharmacy, Bangladesh University, Mohammadpur, Dhaka-1207, Bangladesh | |
| Corresponding Author : | Md. Shah Amran Department of Pharmaceutical Chemistry Faculty of Pharmacy University of Dhaka, Dhaka-1000, Bangladesh Tel: +8801718617915 Fax: +88029667222 E-mail: amranms@ du.ac.bd |
| Received: July 15, 2015 Accepted: August 24, 2015 Published: August 31, 2015 | |
| Citation:Kundu SP, Sultan MZ, Rahman A, Paul SK, Shikder S, et al. (2015) The Study of Analgesic Activity of Complexes of Magnesium Sulfate with Aspirin, Paracetamol and Naproxen. Clin Pharmacol Biopharm 4:143. doi:10.4172/2167-065X.1000143 | |
| Copyright: © 2015 Kundu SP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
The study on interaction and complexation of drug molecules with other drugs and various metal ions is an important field of research in the chemical, biochemical, medicinal and pharmacological point of views. The biological action of the drug-metal complexes may affect stability and usual activities of drugs through changing pharmacokinetic and pharmacodynamic properties. The analgesic activity was evaluated by acetic acid induced writhing test in mice. In this experiment, aspirin with magnesium sulfate at the dose of 300 mg, 600 mg and 1.5 g/60 kg body weight, Paracetamol with magnesium sulfate at the dose of 500 mg, at the dose of 1 g and of 2.5 g /60 kg body weight and Naproxen with magnesium sulfate at the dose of 500 mg, at the dose of 1 g and at the dose of 2.5 g/60 kg body weight at a ratio of 1:1, 1:2 and 2:1. It was observed that % inhibition of writhing test of all complex drug of aspirin, paracetamol and naproxen with magnesium sulfate at different ratio were less than the main drug i.e. analgesic activity were lower than the main drug. It is concluded that magnesium sulfate while formed complex as well as mixed with aspirin, paracetamol and naproxen at different ratio suppress the analgesic activity of main drug.
