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The Second Messengers Ca2+ and cAMP as Potential Therapeutic Targets for the Control of Cancer Progression
Paolo Ruggero Errante, Francisco Sandro Menezes-Rodrigues, Alberto Andrade Leite, Afonso Caricati-Neto and Leandro Bueno Bergantin*Department of Pharmacology, Federal University of São Paulo-Paulista School of Medicine, Laboratory of Autonomic and Cardiovascular Pharmacology, Rua Pedro de Toledo669 - Vila Clementino, São Paulo-SP, Brazil
- *Corresponding Author:
- Leandro Bueno Bergantin
Department of Pharmacology, Federal University of São Paulo-Paulista School of Medicine
Laboratory of Autonomic and Cardiovascular Pharmacology
Rua Pedro de Toledo669 - Vila Clementino, São Paulo - SP, Brazil
Tel: 55 11 5576-4973
E-mail: leanbio39@yahoo.com.br
Received date: July 2, 2017; Accepted date: July 5, 2017; Published date: July 15, 2017
Citation: Errante PR, Rodrigues FSM, Leite AA, Caricati-Neto A, Bergantin LB (2017) The Second Messengers Ca2+ and camp as Potential Therapeutic Targets for the Control of Cancer Progression. Adv Cancer Prev 2:e105. doi:10.4172/2472-0429.1000e105
Copyright: © 2017 Errante PR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the incidence of interruption in antitumoral treatment.
