The Role of Skeletal Muscle Hyperplasia
Received Date: Jul 03, 2023 / Published Date: Jul 28, 2023
Abstract
Beckwith-Wiedemann Syndrome is a rare congenital overgrowth disorder characterized by various clinical features, including macroglossia, gigantism, abdominal wall defects, and increased risk of childhood tumors. While the molecular basis of BWS has been extensively studied, the specific mechanisms underlying the development of macroglossia remain unclear. This study aims to investigate the potential role of skeletal muscle hyperplasia in causing macroglossia in BWS. The keyhole-shaped partial resection revealed a harder posterior side than the anterior. Microscopically, the posterior side consisted of dense subepithelial eosinophilic areas composed of an abundance of tightly packed skeletal muscle fibers that were arranged in a fascicular or storiform pattern. BWS-associated macroglossia results from skeletal muscle hyperplasia, consistent with true macroglossia.
Citation: Bobbly K (2023) The Role of Skeletal Muscle Hyperplasia. J Orthop Oncol 9: 212. Doi: 10.4172/2472-016X.100212
Copyright: © 2023 Bobbly K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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