Abstract

Understanding the Role of Drug Clearance Mechanisms in Therapeutic Efficacy. Drug clearance mechanisms, encompassing renal excretion, hepatic metabolism, and other elimination pathways, critically influence the pharmacokinetic profile of medications. This article explores how variations in clearance mechanisms impact therapeutic efficacy and safety in clinical practice. Renal and hepatic clearance pathways, along with less common routes such as pulmonary and gastrointestinal elimination, are discussed in the context of optimizing drug dosing regimens. Considerations for personalized medicine, including genetic factors and patient-specific characteristics, are highlighted to enhance treatment outcomes and minimize adverse effects