Abstract

The increasing number of hematopoietic cell transplantations (HCTs) performed annually, the evolving demographics of HCT donors, the introduction of novel transplantation techniques, continuous improvements in survival rates, and the expanding population of HCT survivors underscore the need for a comprehensive examination of the health and well-being of individuals post-transplantation. This report provides an overview of strategies for conducting research on late effects after transplantation, including considerations for study design and analytical approaches, methodological challenges associated with handling complex phenotype data, awareness of changing trends in transplantation practices, and the importance of biospecimen repositories to support laboratory-based research. It is anticipated that these insights will facilitate ongoing research efforts and foster the development of innovative approaches to address fundamental questions in the field of transplantation.