The Receptor for Advanced Glycation Endproducts (RAGE) and Mediation of Inflammatory Neurodegeneration
Received Date: Jan 06, 2018 / Accepted Date: Jan 17, 2018 / Published Date: Jan 24, 2018
Abstract
The Receptor for Advanced Glycation Endproducts (RAGE) is an immunoglobulin-type, transmembrane receptor that is expressed on numerous cell types in the Central Nervous System (CNS) and periphery, such as neurons, astrocytes, microglia, mononuclear phagocytes, epithelial cells and endothelial cells (ECs). RAGE binds a discrete repertoire of ligands, including non-enzymatically glycated proteins and lipids, also known as advanced glycation endproducts (AGEs), for which the receptor is named, in addition to multiple members of the S100/calgranulin family, oligomeric forms of Aβ, high mobility group box 1 (HMGB1), phosphatidylserine (PS) and lysophosphatidic acid.
Keywords: Alzheimer’s disease (AD); Cerebrovascular ischemia (CI); Parkinson’s disease (PD); Amyotrophic lateral sclerosis (ALS); Dementia
Citation: Derk J, MacLean M, Juranek J, Schmidt AM (2018) The Receptor for Advanced Glycation Endproducts (RAGE) and Mediation of Inflammatory Neurodegeneration. J Alzheimers Dis Parkinsonism 8: 421. Doi: 10.4172/2161-0460.1000421
Copyright: ©2018 Derk J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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