Abstract

To assess how different nasal and sinus-related clinical disorders relate to the type, location, severity, and occurrence of headaches. The study included all patients who had sinus and nasal infections, both acute and chronic, as well as headaches. Along with clinical, radiographic, and endoscopic assessment, the diagnosis was confirmed. Different parameters are grouped appropriately. The most frequent nasal condition observed in otorhino- laryngology OPD is chronic rhinosinusitis/chronic recurrent rhino sinusitis, which has a major morbidity on the general population as well as a significant economic burden. The headache is the most typical related symptom that requires attention. The type, intensity, and pattern of the headache can help us make the right diagnosis.

A rare and unpleasant primary condition called a cluster headache can manifest itself in episodic or persistent patterns. According to several researchers, the brain area of the hypothalamus, which controls the autonomic nervous system and endocrine function, is involved in the pathophysiology of cluster headaches. According to some writers, people with this condition have impaired glucose metabolism. We administered oral high-dose thiamine to a patient with cluster headaches in light of the function that thiamine plays in the brain, in energy metabolism, and in the regulation of pain. We present a case of a 41-year-old guy who has had main persistent cluster headaches since he was 15 years old. In December 2016, the patient started receiving high-dose thiamine orally. A significant improvement in the symptoms was seen after taking oral thiamine supplements. All of the disease's symptoms were successfully reversed by the treatment. Our research reveals that a thiamine deficit caused by enzymatic abnormalities or by dysfunctional thiamine circulation in the intracellular space may contribute significantly to the aetiology of cluster headache symptoms by impairing neuronal selectivity in the disease-related areas.