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Hindi The Ontogeny of Red Soma Cells
*Corresponding Author: Song Huang, Epithelix, Chemin des Aulx 18, 1228 Plan-les-Ouates, Geneva, Switzerland, Email: song.huang@epithelix.comReceived Date: Mar 31, 2021 / Accepted Date: Apr 16, 2021 / Published Date: Apr 23, 2021
Citation: Huang S (2021) The Ontogeny of Red Soma Cells. J Infect Dis Ther S5:001.
Copyright: © 2021 Huang S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted usse, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
We reported recently our discovery of an important population of red cells in the lungs, distinct from the Red blood cells. They are permanent resident pulmonary cells located in the connective tissues of the lungs, with multiple differentiation potentials and diverse important functions. We named this population of cells, Red Soma Cells. In this article, we try to map out the ontogeny of the Red Soma Cells during mouse lung development. First, based on our knowledge on RSC cells in adult human lungs, we established an “Identikit” of RSC cells: a disk-like shape and pinkcolored after Eosin/Hematoxylin staining on histological sections. Then, with this “Identikit” in mind, we searched for RSC-like cells in the literature on mouse lung development. We found at least 7 lines of evidence, which permitted us to construct a Mind Map on the ontogeny of Red Soma Cells during mouse lung development. This Mind Map allowed us to explain a large amount of experimental data obtained in several different fields, with different analytical tools: Anatomy/Whole lungs, Histology/Lung sections and H/E staining, Genetics/transgenic mice, Gene expression analysis/Whole genome transcriptomes, Developmental Biology/septation and Ontogeny of lung macrophages, etc. Finally, we reached the following conclusion: the mouse Red Soma Cells, probably originated from fetal liver, constitute a unique cell population of Hematopoietic Stem Cells with important roles in mouse lung development.
