The Nature of Destructive and Compensator-Restorative Processes in the Rat Heart Myocardium after a Traumatic Brain Injury Performing Various Physical Exercises
Received Date: Sep 30, 2021 / Accepted Date: Oct 14, 2021 / Published Date: Oct 21, 2021
Abstract
Traumatic brain injury (TBI) is one of the most common causes of disability and is an economic burden for society. The pathophysiological mechanisms of brain damage in TBI are based on the action of primary and secondary damaging factors. Secondary injuries are cascading biochemical, inflammatory, stress reactions, one of which is nonspecific systemic activation of hemostasis caused by hypoxia, an increase in free reactive oxygen species, a slowdown in blood flow, an increase in blood viscosity. The primary aim of this article is to examine the nature of destructive and compensator-restorative processes in the rat heart myocardium after a traumatic brain injury performing various physical exercises. To meet the aim of the study, some experiments have been carried out on outbred laboratory albino rats aged from 21 to 210 days. Meanwhile, the basis for the age periodization of rats is the anatomical and physiological characteristics of animals. The results of the experiments demonstrate that the group of animals with unlimited motor activity (UMA) after 30 days has no recovery of the parameters of cellular structures to the values of the control group. Furthermore, over the first day after modeling the traumatic brain injury, all age groups of experimental animals manifest a decrease in the number of intact neurons and an increase in the number of degenerative changed neurons. Consequently, it can be concluded most desirable mode of physical activity for rats of all age groups is the performance of dynamic exercises in the form of systematic swimming.
Keywords: Compensator-restorative processes; Heart myocardium; Physical exercises; Traumatic brain injury
Citation: Vakhitov BI, Raginov IS, Vakhitov IK, Izosimova AV (2021) The Nature of Destructive and Compensator-Restorative Processes in the Rat Heart Myocardium after a Traumatic Brain Injury Performing Various Physical Exercises. J Alzheimers Dis Parkinsonism S6: 024. Doi: 10.4172/2161-0460.1000024
Copyright: © 2021 Vakhitov BI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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