Abstract

Protein misfiling disorders, as well as the neurodegenerative conditions Alzheimer’s disease (AD) and brain disorder (PD) represents one among the foremost medical challenges or our time. The underlying molecular mechanisms that govern macromolecule misfiling and its links with wellness square measure terribly complicated processes, involving the formation of transiently inhabited however extremely virulent molecular species among the jammed setting of the cell and tissue [1]. All the same, abundant progress has been created in understanding these events in recent years through innovative experiments and therapeutic ways, and during this review we have a tendency to gift an outline of the key roles of antibodies and protein fragments in these endeavours [2]. we have a tendency to discuss specifically however these species square measure getting used together with a spread of powerful organic chemistry and biophysical methodologies, as well as a variety of chemical analysis and microscopic techniques applied not simply in vitro however conjointly in place and in vivo, each to achieve a far better understanding of the mechanistic nature of macromolecule misfolding and aggregation and conjointly to style novel therapeutic ways to combat the family of diseases with that they're associated. This text is an element of a Special Issue entitled: Recent advances in molecular engineering of protein [3]