The Kruppel-like Factor Family, Adipose Tissue Metabolism and Related Diseases
Received Date: Dec 12, 2023 / Published Date: Jan 11, 2024
Abstract
Obesity, diabetes, and cardiomyopathy are the leading causes of death in the world. Therefore, the genetic and transcriptional processes that influence these disease processes are important. Klfs are a transcription factor family with 3 Cysteine2Histidine2 zinc finger proteins and 18 members. Proadipogenic Klfs are Klf4, Klf5, Klf14, and Klf15, while antiadipogenic Klfs are Klf2, Klf3, Klf7, Klf10, and Klf16. Klfs directly associated with diabetes are Klf4, Klf5, Klf7, Klf11, and Klf15. Klfs directly associated with cardiomyopathy are Klf4 and Klf5. The purpose of this review is to shed light on the connections between Klfs and diabetes, obesity, cardiomyopathy, and adipose tissue metabolism
Keywords: The Kruppel-like factor family; Obesity; Diabetes; Cardiomyopathy
Citation: Yuce K, Ozkan AI (2024) The Kruppel-like Factor Family, Adipose Tissue Metabolism and Related Diseases. J Obes Weight Loss Ther S6:003.
Copyright: © 2024 Yuce K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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