Abstract

The Central Nervous System (CNS) has long been regarded as a sanctuary protected from the immune system’s reach. However, recent discoveries have unveiled a dynamic interplay between cytokines, the signaling molecules of the immune system, and the CNS. Cytokines, traditionally associated with immune regulation and inflammation, exert diverse effects on the CNS through various mechanisms. They can penetrate the blood-brain barrier, influence cellular crosstalk within the CNS, and modulate neurotransmitter systems, thus impacting neuronal function and neuro inflammatory responses. This abstract delves into the intricate mechanisms and consequences of cytokine action on the CNS, highlighting its profound implications for neurological function and disease pathogenesis.