Journal of Pediatric Neurological Disorders
Open Access

Mini Review

The Increase of AMP-activated Protein Kinase during Physical Activitiescan Reduce Symptoms of Autistic Children

Bakouie F^1*, Darvishi A², Bahrami S² and Gharibzadeh S¹

¹Institute for Cognitive and Brain Sciences (ICBS), Shahid Beheshti University, Iran

²Student’s Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran

*Corresponding Author:

Bakouie F
Institute for Cognitive and Brain Sciences (ICBS)
Shahid Beheshti University, Iran
Tel: (009821) 2403041
Email: f_bakouie@sbu.ac.ir;

Received date: October 26, 2015 Accepted date: December 08, 2015 Published date: December 15, 2015

Citation: Bakouie F (2015) The Increase of AMP-activated Protein Kinase during Physical Activities can Reduce Symptoms of Autistic Children. J Pediatr Neurosci 1:102. doi: 10.4172/2572-5203.1000102

Copyright: © 2015 Bakouie F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Autism spectrum disorders (ASD) are one of the neurodevelopmental disorders. About one-five of children diagnosed with ASD have regression autism. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is precisely control the balance of ATP metabolism in mitochondria, the organelle that show dysfunction in regressive autism. Studies have shown that this sensor kinase can be effective in axonal growth. It has been suggested that exercise is one of the most powerful factors that increase mitochondrial activity and the amount of AMPK. Above the mentioned, we hypothesized that the physical activities can increase mitochondrial activity and reduce the symptoms of autistic children.

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