Abstract

Background: Therapeutic alliance, defined as the collaborative and affective bond between patient and clinician, plays a crucial role in psychotherapy. However, its impact on pharmacotherapy outcomes in patients with depression and anxiety is less understood. Understanding this dynamic could provide insights into how non-pharmacological factors contribute to treatment success. This systematic review examines the existing literature to assess the effect of therapeutic alliance on pharmacotherapy outcomes in patients diagnosed with depression and anxiety. This review highlights the potential importance of therapeutic alliance in optimizing pharmacotherapy outcomes for patients with depression and anxiety. Integrating alliance-focused strategies in routine pharmacological care may enhance treatment efficacy, though further research is necessary to confirm causality and delineate underlying mechanisms