The Immunomodulation and Myelin Sheath Protection of Bilobalide in Experimental Autoimmune Encephalomyelitis
Received Date: Dec 08, 2020 / Accepted Date: Dec 22, 2020 / Published Date: Dec 29, 2020
Abstract
Bilobalide (BB), a sesquiterpene isolated from Ginkgo biloba extract, has attracted great interest as a potential therapeutic agent for several neurological diseases. Multiple Sclerosis (MS) is a chronic immune-mediated inflammatory and neurodegenerative disease of the Central Nervous System (CNS), which results in demyelination and axonal degeneration. Experimental Autoimmune Encephalomyelitis (EAE), characterized by infiltration of T cells and macrophages, neuroinflammation and severe demyelination, is the best imitation and extensively used to study MS. The recent paper, “The therapeutic potential of bilobalide on Experimental Autoimmune Encephalomyelitis (EAE) mice”, provides evidence that BB protected myelin sheath by immunomodulatory, anti-inflammation and antiapoptosis. In this review, we discussed the findings of BB treatment on EAE.
Keywords: Bilobalide; Neuroprotection; Immunomodulatory; Anti-inflammation; Anti-apoptosis
Citation: Miao Q, Wang Q, Xiao BG, Ma CG (2021) The Immunomodulation and Myelin Sheath Protection of Bilobalide in Experimental Autoimmune Encephalomyelitis. J Clin Exp Neuroimmunol 6: 121 Doi: 10.4172/jceni.1000121
Copyright: © 2020 Miao Q, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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