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Hindi Review Article
The Great Significance of Research into the Physiological Relev ance between AQP4 and Vasopressin for Studying Alzheimers Disease
Yu-Long Lan1,2, Tonghui Ma2, Jie Zhao2,3, Shao Li2*
1Department of Neurosurgery, the First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China
2Department of Physiology, Dalian Medical University, Dalian, 116044, China
3Liaoning Engineering Technology Centre of Target-based Nature Products for Prevention and Treatment of Ageing-related Neurodegeneration, Dalian, 116044, China
- Corresponding Author:
- Shao Li
Department of Physiology
Dalian Medical University
Dalian 116044, China
Tel: +86-411-8611-0352
E-mail: lishao89@hotmail.com
Received date: August 22, 2015; Accepted date: September 14, 2015; Published date: September 21, 2015
Citation: Lan YL, Ma T, Zhao J, Li S (2015) The Great Significance of Research into the Physiological Relevance between AQP4 and Vasopressin for Studying Alzheimer’s Disease. J Alzheimers Dis Parkinsonism 5:192.doi:10.4172/2161-0460.1000192
Copyright: © 2015 Lan YL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Aquaporin 4 (AQP4), which is the predominant aquaporins (AQPs) isoform in the adult brain, is specifically localized to astrocytes. Current findings regarding AQP4 and various neurological diseases have initiated our interest in unraveling the mystery of AQP4 function in Alzheimer’s disease (AD), which is a progressive neurodegenerative disorder characterized by the loss of memory and cognitive disturbances; however, far less is known regarding the precise mechanisms. Vasopressin plays an important role in the regulation of central nervous functions, including learning and memory. Research into vasopressin might contribute to clarification of the neuroprotective effect of AQP4 against AD. Currently the research regarding the functional interaction of AQP4 and vasopressin has demonstrated to be of great significance for studying AD. Here we review the interaction of AQP4 and vasopressin in astrocyte that might have a pivotal role in the regulation of distinct cellular responses directed to neuropretection against AD, as experimental results strongly emphasize the importance of this topic for future investigations.
