Abstract

The integration of genomic data and artificial intelligence (AI) is poised to revolutionize vaccine development, offering unprecedented opportunities to accelerate the discovery and optimization of vaccines. This paper explores how genomic data can enhance the understanding of pathogen biology and host responses, while AI technologies can streamline data analysis, predict vaccine targets, and personalize vaccine formulations. Through a review of recent advancements and case studies, we highlight the transformative potential of these technologies, identify current challenges, and propose future directions for research. Our findings suggest that combining genomic insights with AI-driven approaches will significantly advance the field, improving vaccine efficacy and accelerating responses to emerging infectious diseases.