Journal of Biotechnology & Biomaterials
Open Access

Research Article

The Effects of Carbon and Gold Ion Implanted Surfaces on Neuronal Stem Cells' Functions

¹Department of Engineering Sciences, Division of Bioengineering, Izmir Katip Celebi University, Izmir, Turkey

²Department of Physiology, School of Medicine; Center for Brain Research, Ege University, Izmir, Turkey

³Department of Biomedical Technologies, Izmir Katip Celebi University, Izmir, Turkey

⁴Department of Bioengineering, Ege University, Izmir, Turkey

*Corresponding Author:

Mr. Emel Sokullu
asistant professor, IKCU, Engineering Sciences-Bioengineering Division
Cigli ana yerleskesi, Izmir, Cigli 35620, Turkey
Tel: +905332300582
E-mail: emelsu@gmail.com

Received date: November 28, 2016; Accepted date: January 27, 2017; Published date: February 03, 2017

Citation: Sokullu E, Dağcı T, Gözen O, Ersoy F, Öztarhan A (2017) The Effects of Carbon and Gold Ion Implanted Surfaces on Neuronal Stem Cells’ Functions. J Biotechnol Biomater 7:253. doi:10.4172/2155-952X.1000253

Copyright: © 2017 Sokullu E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Biomaterials have been used in medicine for decades to improve the functions of tissues and organs. They are also used as prosthesis and implants which are designed to substitute functions of a lacking organ or tissue. Carbon (C) and Gold (Au) were particularly chosen due to their biocompatibility and applied as implants for decades. Carbon and gold were great ion sources for medical applications, as well. In this study, polystyrene dishes were modified using gold and carbon ions via ion implantation technique. Using this surface modification method, it was aimed to improve surface characteristics and achieve a bioactive surface for neural stem cells. Even though the integration of stem cells was promising, neural stem cell studies still have many milestones to reach. Neuro-regeneration was the most desired function for people who suffer from neural system diseases. Changing surface characteristics of scaffolds was a way to promote regeneration and ion implantation was one of the methods to modify surface properties which play a huge role in enhancing the proliferation and integration of cells. In this study, it was observed that the ion implantation stimulated the neural proliferation and the implantation of different ions on cell culture surfaces was essential to determine the effects of this technique on adhesion, proliferation, differentiation and apoptosis properties of cells in details.

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