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The Effect of Oral Melatonin Premedication on Pneumatic Tourniquet Induced Ischemia Reperfusion Injury in Lower Extremity Operations
| Tuba Berra Saritas1,*, Sadik Buyukbas2, Kevser Peker3, Hale Borazan1, Kemal Basarali4, Ibrahim Tuncay5, Alper Kiliçarslan1 and Seref Otelcioglu1 | |
| 1Department of Anesthesiology and Reanimation, Meram Medical School, Necmettin Erbakan University, Konya, Turkey | |
| 2Department of Biochemistry, Meram Medical School, Necmettin Erbakan University Konya, Turkey | |
| 3Kırşehir Ahi Evran University, Government Hospital, Kırşehir, Turkey | |
| 4Dicle University Medical School, Diyarbakır Turkey | |
| 5Department of Orthopaedics, Bezmi Alem University, Istanbul, Turkey | |
| Corresponding Author : | Saritas TB Assistant Professor, Department of Meram Medical School Anesthesiology and Reanimation Necmettin Erbakan University, Konya, Turkey Tel: +905443664244 Fax: +903322236181 E-mail: tsaritas@konya.edu.tr |
| Received: April 24, 2015 Accepted: October 27, 2015 Published: October 30, 2015 | |
| Citation: Saritas TB, Buyukbas S, Peker K, Borazan H, Basarali K, et al. (2015) The Effect of Oral Melatonin Premedication on Pneumatic Tourniquet Induced Ischemia Reperfusion Injury in Lower Extremity Operations. J Pain Relief 4:208.doi:10.4172/21670846.1000208 | |
| Copyright: © 2015 Saritas TB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
| Related article at Pubmed, Scholar Google | |
Abstract
Purpose: Melatonin is a well-known antioxidant molecule and protector against ischemia reperfusion (I/R) injury. It has a tissue protective effect against I/R injury. Methods: We aimed to evaluate the effect of oral melatonin, on I/R injury in patients undergoing arthroscopic knee surgery under spinal anaesthesia.
Methods: Malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO), haemodynamics, respiration rate, atropine and efedrin need, sedation scores were all measured for this purpose.
New Results: There were no significant differences between groups in terms of age, weight, height, sex, ASA classification, BMI, tourniquet time and operation time. Plasma concentrations of MDA increased after ischemia (AI) and decreased at the 15 min of reperfusion (AR) but these results are not statistically significant (p>0.05). Plasma NO levels of Group C were significantly increased when compared to baseline values and Group M at AI period. It decreased significantly in both of the groups AR. Plasma SOD levels in preischemia period increased significantly in both of the groups. Also decreased significantly compared to AI period, and increased significantly compared to basal values in both of the groups.
Conclusions: In conclusion 3 mg oral melatonin does not reduce I/R injury in skeletal muscle after pneumatic tourniquet application in human. It may reduce I/R injury in skeletal muscle in higher doses. So future investigation may be necessary to clarify if melatonin decreases I/R injury model of human skeletal muscle and at what dose or not.
