The Effect of Antiviral Agents in the Treatment of COVID-19 Patients: A Propensity Score-Matched and a Stabilized Inverted Probability of Treatment Weight Study (SIPTW)
Received Date: Jul 20, 2021 / Accepted Date: Aug 04, 2021 / Published Date: Aug 11, 2021
Abstract
Earlier purpose: To evaluate the antivirals casual effects in the treatment of COVID-19 patients, focusing on recovery, the need for home oxygen therapy on discharge and in-hospital mortality.
Methods: A retrospective study of the admitted COVID-19 patients, the outcomes assessed were effect-difference between antivirals and controls for recovery, mortality, and the need for home oxygen. A Propensity Score Matched-Patients (PSM), variables entered for patients were age, gender, documented fever, tobacco, body mass index, LDH level, ferritin level, antivirals, imaging severity categories, D-dimer level, oxygen saturation. Other variables were excluded for multicollinearity. Outcomes were inferred from the PSM-adjusted patients and Stabilized Inverse Probability of Treatment Weight (SIPTW) analysis.
Results: All cohort and PSM-adjusted patients were described. Mortality was for 143 (12.7%) patients in the ICU was 124 (55.8%). SIPTW analysis demonstrated no significant difference between the antiviral treatment arm and control patients in recovered (P=NS), the need for home oxygen therapy (P=NS), and the difference in all-cause mortality between the treatment and control groups (P=NS). On multivariate analysis, recovery, the need for home oxygen and mortality with both favipiravir and remdesivir was not significantly different.
Conclusion: There was no evidence of significant benefit from the antiviral therapy in the treatment of COVID-19 patients in recovery, home oxygen requirements, and death.
Keywords: Remdesivir; Favipiravir; COVID-19 mortality; Recovery; Home oxygen therapy
Citation: Al Ramahi JW, Matar A, Hasan N, Al-Ali MM, Abdulhadi L, et al. (2021) The Effect of Antiviral Agents in the Treatment of COVID-19 Patients: A Propensity Score-Matched and a Stabilized Inverted Probability of Treatment Weight Study (SIPTW). J Infect Dis Ther 9:471. Doi: 10.4172/2332-0877.1000471
Copyright: © Al Ramahi JW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
