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Hindi Research Article
The Dietary Supplement EGCG: NOPE(N-Oleyl- Phosphatidyletathanolamine and pigallocatechin-3-Gallato Formula)Helps Patients to Follow a Flexible Dietary Regimen and Induces Loss of Weight in Patients who had Previously Experienced No Response to Other Weight Loss Intervention
| Daniele Barbaro*, Anna Menasci, Barbara Baldini, Cristina Pasquini and Paola Lapi | |
| Section of Endocrinology, ASL6 Livorno, Italy | |
| Corresponding Author : | Daniele Barbaro Section of Endocrinology, ASL 6 Livorno Viale Alfieri 36 57100 Livorno, Italy Tel: +390586223017 Fax:+390586223380 E-mail: danielebarbaro@katamail.com |
| Received November 24, 2011; Accepted December 14, 2011; Published December 20, 2011 | |
| Citation: Barbaro D, Menasci A, Baldini B, Pasquini C, Lapi P (2011) The Dietary Supplement EGCG: NOPE ( N-Oleyl-Phosphatidyletathanolamine and Epigallocatechin-3-Gallato Formula) Helps Patients to Follow a Flexible Dietary Regimen and Induces Loss of Weight in Patients who had Previously Experienced No Response to Other Weight Loss Intervention. J Obes Weig los Ther 1:105. doi:10.4172/2165-7904.1000105 | |
| Copyright: © 2011 Barbaro D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Background and aims:Obesity is increasing in all countries. The aim of this study was that of evaluating if the treatment with the dietary supplement ( N-oleyl-phstatidylethanolamine and epigallocatechin-3-gallato formula, EGCG-NOPE) could help patients to follow a flexible dietary regimen.
Methods:38 patients (20 males, 18 females, BMI 32-41, aged 33-72 years) were enrolled consecutively. These patients were subjects who had experienced no loss of weight during an intervention program consisting of a short training period, aimed at behaviour modification, followed by a dietary program based on rules of diet, without a fixed amount of calories. These patients were instructed to take EGCG-NOPE, two capsules (EGCG 120 mg and NOPE170 mg each capsule) at 1 hour before lunch and dinner, for two months. The study had a crossover design, and after two months EGCG-NOPE was stopped, the patients continuing to follow only the prescribed dietary rules. After a further two months, patients again took EGCG-NOPE for two more months. The primary end-point of the study was weight loss and a decrease in hip circumference, while the secondary end-point involved metabolic parameters: serum glucose, Homeostasis Model Assessment (HOMA) index, serum LDL and HDL cholesterol and triglycerides.
Results: After two months of treatment with EGCG-NOPE, the weight loss was 2.42kg+/-0.3 (p<0.001), and the decrease in hip circumferences was 2.0 cm +/- 0.2 (p<0.001).There was also a decrease in serum glucose (0.083 mm/L p<0.001), HOMA index (0.48 p<0.001), serum LDL cholesterol (0.46 mm/L p< 0.01), and serum triglycerides (0.25 mm/L p<0.001). HDL cholesterol increased by 0.20 mm/L (p<0.01). Following the two months without treatment, the weight and hip circumference were steady. After the next two months of treatment, the patients had a further loss of weight (2.10 kg +/-0.4 p < 0.01) and a further decrease in hip circumference (2.0 +/- 0.1 p < 0.001).
Conclusions: EGCG-NOPE, at these doses, has shown that it is capable of decreasing the body weight and hip circumferences in patients who had failed to lose weight during a previous dietary regimen. The improvement in the metabolic parameters during treatment with EGCG-NOPE represents a further aspect of paramount importa
