Journal of Mucosal Immunology Research
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Mini Review   
  • J Mucosal Immunol Res,

The Crucial Role of Metabolism in Macrophage Activation

Kenji Izuhara*
Department of Immunology, the University of Tokyo, Japan
*Corresponding Author : Kenji Izuhara, Department of Immunology, The University of Tokyo, Japan, Tel: 819342576091, Email: Izuhara.kenji@gmail.com

Received Date: Aug 30, 2022 / Published Date: Sep 28, 2022

Abstract

Macrophages are essential to the immunological responses associated with atherosclerosis. Recent research on the role of macrophage autophagy (AP) in the development of atherosclerosis has shown a brand-new mechanism by which these cells contribute to vascular inflammation. The transport of cytoplasmic contents to the lysosomal apparatus during AP is a cellular catabolic process that will ultimately result in destruction and recycling. In the early stages of atherosclerosis, basal levels of macrophage AP are crucial for atheroprotection. However, AP deficiency promotes vascular inflammation, oxidative stress, and plaque necrosis in the latter phases of the pathophysiology when it becomes dysfunctional. In this essay, we’ll talk about the involvement of macrophages and AP in atherosclerosis and the growing body of research proving that macrophage AP contributes to vascular disease. We will finally talk on how AP might be targeted for therapeutic utility.

Citation: Izuhara K (2022) The Crucial Role of Metabolism in Macrophage Activation. J Mucosal Immunol Res 6: 156.

Copyright: © 2022 Izuhara K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Top