The Blood-Brain Barrier and Bioenergetics in Stroke
Received Date: Jul 02, 2020 / Accepted Date: Jul 16, 2020 / Published Date: Jul 23, 2020
Abstract
Stroke is an overwhelming neurological disease with very limited treatment options. As blood-brain barrier (BBB) integrity is well-implicated in the prevention of brain injury, its regulation may prove beneficial for stroke patients. BBB cerebro-vascular endothelial cells primarily utilize mitochondria as their energy-producing source, and mitochondrial function has revealed importance in outcomes for tissue post-stroke. In this review, bioenergetics in relation to BBB permeability in stroke is discussed. Moreover, what causes mitochondrial dysfunction following stroke is explored.
Keywords: Blood brain barrier; BBB; Mitochondria; Bioenergetics; Stroke; Ischemia
Citation: Hone E, Sarvari S, Moakedi F, Liu Y, Ren X (2020) The Blood-Brain Barrier and Bioenergetics in Stroke. J Neuroinfect Dis 11: 298. Doi: 10.4172/2314-7326.1000298
Copyright: © 2020 Hone E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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