Abstract

Targeted drug delivery to the brain is a critical endeavor in the field of biopharmaceutics, particularly for treating neurological disorders. The blood-brain barrier (BBB) poses a significant challenge to delivering therapeutic agents to the central nervous system (CNS). Recent breakthroughs in drug delivery technologies offer promising avenues for overcoming these barriers and revolutionizing the treatment of neurological disorders. This article reviews the latest advances in targeted drug delivery to the brain, including nanoparticle technology, blood-brain barrier disruption techniques, and cell-based delivery systems. Additionally, it discusses the challenges and future directions in the field, including improving BBB penetration efficiency, ensuring safety and biocompatibility, and facilitating clinical translation.