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T Cell Subpopulations, CCR5 and CXCR4 in Discordant Couples when Compared with Concordant and Healthy Control Subjects
Yohannis M Hambissa1*, Yohannes Mengistu2, Dawit Wolday3, Aster Tsegaye4, Rawley C Howe5, Nick Anderson6, Ermias Hailu7 and Tsehaynesh Messele81Kotebe University College, Addis Ababa, Ethiopia
2Mauricio’s, Botswana, South Africa
3Medical Biotech Laboratory, Addis Ababa, Ethiopia
4Department of Medical Laboratory Science, Addis Ababa University, Addis Ababa, Ethiopia
5Armour Hansen Research Institute (AHRI), Addis Ababa, Ethiopia
7Ethiopian Health and Nutrition Research Institute (EHNRI), Addis Ababa, Ethiopia
8African Society for Laboratory Medicine (ASLM), Bole Road, Behind Friendship Building, Bole sub- city, Kebele 02, Addis Ababa, Ethiopia
- *Corresponding Author:
- Yohannis Meseret Hambissa
Kotebe University College, Addis Ababa, Ethiopia
Tel: 251911627786
E-mail: yohannis_meseret@yahoo.com
Received date: February 02, 2017; Accepted date: February 13, 2017; Published date: February 17, 2017
Citation: Hambissa YM, Mengistu Y, Wolday D, Tsegaye A, Howe RC, et al. (2017) T Cell Subpopulations, CCR5 and CXCR4 in Discordant Couples when Compared with Concordant and Healthy Control Subjects. J Mol Immunol 2:107.
Copyright: © 2017 Hambissa YM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Analysis of T cell subpopulations in discordant couples showed no activation of a specific marker between discordant positives and negatives and the expression of T cell subpopulations was comparable. The expression of activation markers was in significantly (P<0.05) higher in concordant couples compared with discordant positives and apparently healthy control, indicating lower immune activation in discordant couples. Moreover, we observed in discordant positives, certain markers (CD4+CD45RA-CD27-) in a high proportion (>30%), similar to non-progressors. CCR5 co receptors were significantly (P<0.05) lower in discordant couples when compared with concordant couples and healthy control. In discordant negatives CD4 and CD8 cells were higher similar with healthy negative controls. Unlike the concordant couples, immune activation markers were significantly low and expressed significantly lower CCR5 receptors. However, high memory T-cells was observed.
