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Hindi Research Article
Synthesis of Dihydroimidazole Derivatives under Solvent Free Condition and Their Antibacterial Evaluation
| Mahmoud Abd El Aleem Ali Ali El-Remaily1*, Shaaban K Mohamed2, Ahmed MM Soliman1, and Hossam Abd el-Ghanya1 | |
| 1Department of Chemistry, Sohag University, Egypt | |
| 2School of Chemistry and Environmental Science, Manchester Metropolitan University, Manchester, England | |
| *Corresponding Author : | Abd El Aleem Ali Ali El-Remaily Department of Chemistry Sohag University, Sohag 82524, Egypt Tel: +20108036348 Fax: +2093601159 E-mail: msremaily@yahoo.com |
| Received July 03, 2014; Accepted July 25, 2014; Published August 01, 2014 | |
| Citation: Ali El-Remaily MAEAA, Mohamed SK, Soliman AMM, Abd el-Ghanya H (2014) Synthesis of Dihydroimidazole Derivatives under Solvent Free Condition and Their Antibacterial Evaluation . Biochem Physiol 3:139. doi:10.4172/2168-9652.1000139 | |
| Copyright: © 2014 Ali El-Remaily MAEAA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Reaction of 2-guanidinobenzoxazole with several halogenated active methylene compounds has revealed formation of the corresponding dihydroimidazole derivatives under solvent free conditions in excellent yield. The anti-bacterial evaluation of the newly synthesized products against different types of Gram-positive and Gramnegative bacteria was performed. Most of products showed high inhibitory effect. The structure of all compounds has been characterized by on IR, 1H-NMR, 13C-NMR, Mass spectrum and some X-ray diffractions.
