Abstract

The rise of immunotherapy (IT) as an oncological treatment option has significantly improved outcomes in a variety of disease states. However, due to the distinct immunologic tumor microenvironment, its application in CNS tumors is still limited for a few reasons. Accordingly, it is significant to consider the convergence of IT with extra treatment techniques that might further develop admittance to the CNS and viability of existing IT modalities. Combining IT with localized hyperthermia (HT) generated by technologies like laser interstitial thermal therapy (LITT) is one such combination. The far-reaching immunomodulatory impacts of restricted and entire body HT have been explored for quite a while. Hyperthermia has exhibited immunostimulatory impacts at the degree of cancer cells, invulnerable cells, and the more extensive climate administering possible safe reconnaissance. An exhaustive comprehension of these impacts as well as the current and forthcoming examinations of such in mix with IT is significant in considering the future headings of neuro-oncology.