ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Synaptic Function and Dysfunction in Alzheimer's Disease

Origlia N1* and Domenici L1,2*

1Neuroscience Institute of the National Council of Research (CNR), 56124 Pisa, Italy

2Department of Applied Clinical Sciences and Biotechnology (DISCAB), University of L’Aquila, 67100 L’Aquila, Italy

Corresponding Authors:
Luciano Domenici
Department of Applied Clinical Sciences and Biotechnology (DISCAB)
University of L’Aquila, 67100 L’Aquila, Italy
Tel: +390503153193
E-mail: domenici@in.cnr.it

 

Nicola Origlia
Neuroscience Institute of the National Council of Research (CNR)
56124 Pisa, Italy
Tel: +390503153193
E-mail: origlia@in.cnr.it

Received date: May 20, 2017; Accepted date: June 20, 2017; Published date: June 27, 2017

Citation: Origlia N, Domenici L (2017) Synaptic Function and Dysfunction in Alzheimer’s Disease. J Alzheimers Dis Parkinsonism 7:341. doi:10.4172/2161- 0460.1000341

Copyright: © 2017 Origlia N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Abstract

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease, primarily affecting the elderly. Pathophysiological mechanisms have been elucidated in the past decades. First of all, AD is progressive leading to cognitive deficits till dementia. Pathologically, AD features synaptic dysfunction with changes of neuronal circuitry, progressive accumulation of protein aggregates such as the beta amyloid and tau. Herein we critically review neurobiological processes and factors involved in AD, in light of recent results on synaptic dysfunction and impairment of neuronal activity.

Keywords

https://bahigox.fun/ https://bahisjet.fun/ https://bahsegel.fun/ https://betboo.fun/ https://betdoksan.xyz/ https://betebetgiris.xyz/ https://betexper.fun/ https://betgram.fun/ https://betkanyon.fun/ https://betkolik.fun/
Top