Abstract

Huntingtin-associated protein 1 (HAP1) is a neuronal cytoplasmic protein that is predominantly expressed in the intelligence and spinal cord. In addition to the central worried system, HAP1 is additionally expressed in the peripheral organs such as endocrine system. Different kinds of enteroendocrine cells (EEC) are current in the digestive organs. To date, the characterization of HAP1-immunoreactive (ir) cells remains unreported there. In the existing study, the expression of HAP1 in pyloric belly in grownup male rats and its relationships with specific chemical markers for EEC [gastrin, marker of gastrin (G) cells; somatostatin, marker of delta (D) cells; 5-HT, marker of enterochromaffin (EC) cells; histamine, marker of enterochromaffin-like (ECL) cells] had been examined using single- or double-labelled immunohistochemistry and with light-, fluorescence- or electron-microscopy.