Abstract

Where simple, accurate, precise and rapid spectrophotometric method was developed for the assessment of mometasone furoate (MF) and tolnaftate (TF) in pure form and pharmaceutical preparations. These methods depend on the interaction between cited drugs with eriochrome black T (EBT), methyl orange (MO) and Chrome azurol S (CRS) in acidic buffers forming ion-pair complexes, after extracting in chloroform and measured quantitatively with maximum absorption at 510, 440 and 530 nm for MF with EBT, MO and, CRS, respectively, and at 550, 482 and 499 nm for TF with EBT, MO and, CRS, respectively. The extracts are colored and stable for 30 minute at room temperature. The linearity ranges of the methods were 3-15 μg/mL for MF with EBT, MO, and CRS and 1-5 μg/mL for TF with EBT, MO, and CRS. The stoichiometry of the complexes was found to be 1:1 in all cases except of (CRS:TF) it was found (1:2). The analytical parameters were evaluated and the obtained results were statistically compared with that of reported methods. Comparisons were starting to show that there is no significant difference regarding both accuracy and precision. The proposed methods can be suggested for routine analysis and quality control where time and cost effectiveness of analytical approaches are critical.

Keywords: Mometasone furoate; Tolnaftate; Eriochrome black T, Methyl orange; Chrome Azurol S; Ion-pair complex