Specific Quality of Sensation Derived from the Pain-Spots
Received Date: Nov 24, 2022 / Published Date: Dec 22, 2022
Abstract
The most common type of cannabinoid is the tetra-hydrocannabinol, which is one of the major psychoactive components isolated from Cannabis sativa. Cannabinoids can bind to Gi-protein coupled cannabinoid type 1 receptors, which is highly expressed in the pre- and post-synaptic in brain and spinal cord, as well as the Gi-proteincoupled cannabinoid type 2 receptors that is predominantly located in the immune system. The activation of CB1 and CB2 inhibits the formation of intracellular cAMP, hence leading to a tremendous reduction of the excitatory effect within the neurons.
Keywords: Cannabinoid; Pain sensation; Receptors; Neurokinin;Spinal cord; Pain pathway
Citation: Cain JG (2022) Specific Quality of Sensation Derived from the Pain- Spots. J Pain Relief 11: 474. Doi: 10.4172/2167-0846.1000474
Copyright: © 2022 Cain JG. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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