Abstract

Inflammatory diseases pose significant challenges in treatment due to their chronic nature and complex pathophysiology. Smart nanocarriers have emerged as promising platforms for delivering therapeutics with precision and efficacy. This article reviews the design principles, mechanisms, and recent advancements in smart nanocarriers for controlled release of therapeutics in inflammatory diseases. Key strategies for targeting inflamed tissues, modulating immune responses, and enhancing therapeutic outcomes are discussed, highlighting the transformative potential of nanotechnology in personalized medicine.