Archives of Science
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Mini Review   
  • Arch Sci 2023, Vol 7(1): 143
  • DOI: 10.4172/science.1000143

Sleep Development in Drosophila is governed by the Intrinsic Maturation of Sleep Output Neurons

Cecilia Martin*
Department of Animal Physiology, College of Essex, United Kingdom
*Corresponding Author : Cecilia Martin, Department of Animal Physiology, College of Essex, United Kingdom, Email: Cecmar@yahoo.com

Received Date: Jan 03, 2023 / Published Date: Jan 30, 2023

Abstract

Sleep ontogeny, or the growth of sleep behaviour across a lifespan, is an enduring feature of evolution. Studies on mammals have revealed that, in addition to having longer sleep intervals, early life sleep differs significantly from adult sleep in terms of its many sleep stages. It is unclear how intrinsic sleep output circuit maturation affects the development of sleep. Between juvenile and adulthood, the fruit fly Drosophila melanogaster experiences a variety of sleep-related alterations. Here, we study the differences between the sleep architecture of juvenile and mature flies using a non-invasive probabilistic method. The main cause of increased sleep in young flies is a lower likelihood of waking up, which is accompanied by longer periods of deeper sleep. Sleep-promoting neurons in the dorsal fan-shaped body (dFB) have been functionally altered, and this research suggests that these neurons regulate sleep differently in juvenile and older flies. The genes involved in the maturation of the dFB sleep circuit are implicated by transcriptomic analysis of dFB neurons at various ages and a subsequent RNAi screen. These findings indicate that alterations in sleep across the lifetime are influenced by the changing transcriptional statuses of sleep output neurons.

Keywords: Sleep; Drosophila; Ontogeny development

Citation: Martin C (2023) Sleep Development in Drosophila is governed by the Intrinsic Maturation of Sleep Output Neurons. Arch Sci 7: 143. Doi: 10.4172/science.1000143

Copyright: © 2023 Martin C. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Top