Abstract

Biomaterials play a pivotal role in tissue repair and regeneration, offering innovative solutions to address the challenges in healing damaged tissues and organs. The design and development of biomaterials for tissue repair are guided by the principles of biocompatibility, bioactivity, and biomechanical properties. Various biomaterials, including synthetic polymers, natural polymers, ceramics, and composites, have been engineered to mimic the Extracellular Matrix (ECM) and provide structural support, promote cell adhesion, proliferation, and differentiation, and modulate the tissue microenvironment. This abstract provides a comprehensive overview of the significance of biomaterials in tissue repair, highlighting recent advancements, applications, and future prospects. In the field of regenerative medicine, biomaterials serve as scaffolds, delivery vehicles for bioactive molecules, and platforms for tissue engineering and organ transplantation. Scaffold-based approaches offer spatial organization and mechanical support for cells, facilitating tissue regeneration in complex biological environments. Furthermore, the integration of growth factors, cytokines, and genetic materials into biomaterial matrices enhances their therapeutic efficacy, promoting angiogenesis, immunomodulation, and tissue remodeling.