Journal of Alzheimers Disease & Parkinsonism
Open Access

Research Article

Shanghai Cohort Study on Mild Cognitive Impairment: Study Desig n and Baseline Characteristics

Bin Zhou^1*, Qianhua Zhao², Shinsuke Kojima¹, Ding Ding², Yoji Nagai¹, Qihao Guo³, Masanori Fukushima¹ and Zhen Hong^2,3

¹Translational Research Informatics Center Foundation for Biomedical Research and Innovation, Kobe, Japan

²Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China

³Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China

Corresponding Author:

Bin Zhou
Translational Research Informatics Center
Foundation for Biomedical Research and Innovation
1-5-4 Minatojimaminamimachi, Chuo-ku, Kobe, Japan 650-0047
Tel: +81-78-3039093
E-mail: zhoubin@tri-kobe.org

Received date: March 03, 2016; Accepted date: March 17, 2016; Published date: March 24, 2016

Citation: Zhou B, Zhao Q, Kojima S, Ding D, Nagai Y, et al. (2016) Shanghai Cohort Study on Mild Cognitive Impairment: Study Design and Baseline Characteristics. J Alzheimers Dis Parkinsonism 6:224. doi:10.4172/2161-0460.1000224

Copyright: © 2016 Zhou B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Objective: Establish cohort of patients with mild cognitive impairment (MCI) in order to identify the risk factors and validation of neuropsychological tests for early detection of Alzheimer disease.

Methods: Four hundred participants with MCI were enrolled in at Huashan Hospital in Shanghai, China. All patients will be followed once annually for 3years. The primary endpoint is the time of conversion from diagnosis of MCI to Alzheimer disease (AD).

Results: of the 400 subjects, 170 (42.5%) were male, and the average mean age and education was 68.7 (Standard Deviation, SD: 8.2, 45- 90 years old) and 12 years (SD: 3.1), respectively. At baseline age, education and being single influenced MMSE, ADAS-cog13 and most domains of cognition.

Conclusions: Baseline characteristics of the Shanghai MCI cohort study indicate the participants were younger, less educated and had a moderate gender ratio compared to other studies conducted so far and represent the target population. 3 years later when the cohort will be finished some risk factors Associated with the conversion will be validated and some novel factors will be identified.

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