Abstract

Fetal angiotensin-converting enzyme (ACE) protein deficiency is a rare condition associated with significant morbidity and mortality. This deficiency leads to impaired production of angiotensin II, resulting in severe oligohydramnios and pulmonary hypoplasia. Current management options are limited, and outcomes are often poor. Here, we present a case study of sequential amnioinfusion as a novel therapeutic approach for fetal ACE protein deficiency. This intervention involved repeated infusion of sterile fluid into the amniotic cavity to restore amniotic fluid volume and support fetal lung development. Our results demonstrate improvements in fetal lung growth and amniotic fluid levels following sequential amnioinfusion, suggesting the potential utility of this approach in managing fetal ACE protein deficiency. Further research is warranted to validate these findings and optimize treatment protocols for improved outcomes in affected pregnancies.