Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Research Article
Sensitive Spectrophotometric and Conductometric Methods for the Determination of Candesartan Using Acidic Dyes
| Alaa S Amin1*, Hanna M Salah2, Gamal H Ragab2 and Inass S Kamel2 | |
| 1Chemistry Department, Faculty of Science, Benha University, Benha, Egypt | |
| 2Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | |
| *Corresponding Author : | Alaa S. Amin Chemistry Department, Faculty of Science Benha University, Benha, 2345, Egypt Tel: 0020105090599 Fax: 0020132222578 E-mail: asamin2005@hotmail.com |
| Received February 25, 2015; Accepted March 06, 2015; Published March 13, 2015 | |
| Citation: Amin AS, Salah HM, Ragab GH, Kamel IS (2015) Sensitive Spectrophotometric and Conductometric Methods for the Determination of Candesartan Using Acidic Dyes. Biochem Physiol 4:153. doi:10.4172/2168-9652.1000153 | |
| Copyright: © 2015 Amin AS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Two simple, sensitive, accurate, rapid spectrophotometric and conductometric methods were developed for the determination of candesartan (CAND) in raw material and in its pharmaceutical preparation. The proposed methods depend upon the reaction of bromocresol green (BCG) or bromocresol purple (BCP) with candesartan in phosphate buffered solution to form stable colored ion-pair complex, which was extracted in chloroform. The yellow colored complexes were determined at λmax 415, 405 nm with BCG, BCP, respectively. Using conductometric titration, candesartan could be evaluated in acetone. The optimizations of various experimental conditions were described. The results obtained showed good recover of 100.14 (n=6) with relative standard deviation of 0.62 (n=6). Applications of the proposed methods to representative pharmaceutical formulations are successfully presented compared with official methods.
