Abstract

In-depth study is being done on the secretome formed from dental pulp a stem (DSC) cell, which is made up of a variety of biomolecules, and its therapeutic potential. Because the paracrine effect of the bioactive factors secreted by human dental pulp stem cells (hDPSCs) and human exfoliated deciduous teeth (SHEDs) is not fully understood, the majority of DSC secretome-based therapies have not been applied in human medicine, despite promising in vitro and in vivo studies. We summarise the available research on the secretome produced from hDPSC and SHED as a possible participant in the regeneration of bone, cartilage, and nerve tissue in this review. According to published studies, dental MSC-derived secretome/conditional medium can regulate neuroprotective, anti-inflammatory, anti-apoptotic, and angiogenic processes through secretome paracrine mechanisms, which may be useful in treating neurodegenerative diseases, neural injuries, cartilage defects, and bone repair. Similar to bone marrow MSC-secretomes, dental MSCsecretomes engage cellular and molecular pathways that affect how well cell-free therapy works. The multidirectional paracrine effect that dental MSC-derived secretomes have been shown to have in the treatment of numerous different wounded tissues is emphasised in many papers as having potential applications in tissue-regenerating therapy [1].