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Rust on the Brain from Microbleeds and Its Relevance to Alzheimer Studies: Invited Commentary on Cacciottolo Neurobiology of Aging, 2016
Cacciottolo M1, Morgan TE1and Finch CE1,2*1Leonard Davis School of Gerontology, Los Angeles CA, USA
2Department of Neurobiology, Dornsife College, University of Southern California, Los Angeles CA, USA
- *Corresponding Author:
- Finch CE
Department of Neurobiology, Dornsife College
University of Southern California
Los Angeles CA, USA
Tel: 12133697600
E-mail: cefinch@usc.edu
Received date: November 04, 2016; Accepted date: November 17, 2016; Published date: November 24, 2016
Citation: Cacciottolo M, Morgan TE, Finch CE (2016) Rust on the Brain from Microbleeds and Its Relevance to Alzheimer Studies: Invited Commentary on Cacciottolo Neurobiology of Aging, 2016. J Alzheimers Dis Parkinsonism 6:287. doi:10.4172/2161-0460.1000287
Copyright: © 2016 Cacciottolo M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Cerebral microbleeds (MB) and small vessel disease (SVD) with congophilic arterial angiopathy (CAA) are increasingly recognized as a variable factor in AD cognitive impairments. This commentary on our recent report on sex-ApoE interactions in MBs published this February, briefly explores three aspects of MBs that could not be fully discussed therein: I, A possible gap between the prevalence of MBs as detected by MRI and post mortem analysis; II, The role of hemoglobin- degradation products in amyloid-attributed neurodegenerative changes; and III, Possible assessment of MB by cerebrospinal fluid (CSF) assays for iron-related markers to better screen patient subgroups for AD interventions.
