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Hindi Research Article
RP-HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF EPROSARTAN MESYLATE IN PHARMACEUTICAL PREPARATIONS
Abstract
Objective: A simple, specific, accurate and precise Rp-high-performance liquid chromatography method was developed and validated for determination of Eprosartan Mesylate in pharmaceutical preparations. Materials and Methods: The method showed a linear response for concentrations in the range of 2-12 μg/mL using Methanol: Acetonitrile: Buffer solution (Dissolve 0.02 M potassium di-hydrogen orthophosphate in water. Adjust pH of solution to 6.85 with orthophosphoric acid) in the ratio (45:45:10) as the mobile phase with detection at 233 nm and a flow rate of 1 mL/min and retention time 7.1 min. The value of correlation coefficient, slope and intercept were, 0.9998, 1661.8 and 114.82, respectively. The method was validated as per ICH guidelines for precision, recovery, ruggedness and robustness. The specificity of the method was investigated under different stress conditions including acidic, basic, photochemical and thermal as recommended by ICH guidelines. Conclusions: The method was validated and successfully used for determination of the drugs in tablets.
