Role of the TLR4 rs4986791 Polymorphism in the Development of Lateonset Alzheimer Disease and its Relationship with APOE*4
Received Date: Mar 09, 2018 / Accepted Date: Apr 05, 2018 / Published Date: Apr 14, 2018
Abstract
Objective: Based on that the association of the ε4 allele of the APOE gene with the development of late-onset AD is one of the strongest and that TLR4 has been involved in AD pathogenesis. The aim of the present work was to study the role of rs4986791 polymorphism of the TLR4 gene in the development of AD and correlate any such association with the presence of allele ε4 of the APOE gene. Methods: We included 161 unrelated Venezuelan subjects classified as either AD patients (n=61) or healthy individuals (n=100). Polymorphisms of TLR4 and APOE genes were identified with PCR-SSP and PCR-RFLP, respectively.
Results: The rs4986791 polymorphism does not appear to be related to AD, although the presence of the CC genotype and the C allele apparently confers three times higher risk of developing AD. Finally, positive and negative associations among the combinations TLR4 /APOE genes and AD were observed.
Conclusion: The results suggest the absence of any association between rs4986791 polymorphism of TLR4 gene and susceptibility to AD and the association of the ε4 allele of the APOE gene with the development of this pathology was confirmed.
Keywords: Neurodegenerative disorder; Aged tissues; Chronicinflammation
Citation: Romero R, Salazar Alcalá E, Cedeño N, Fernández-Mestre M (2018) Role of the TLR4 rs4986791 Polymorphism in the Development of Late-Onset Alzheimer Disease and its Relationship with APOE*4. J Alzheimers Dis Parkinsonism 8: 436. Doi: 10.4172/2161-0460.1000436
Copyright: ©2018 Romero R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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