Role of In-silico modeling in Drug Development for Inhalation Treatment
Received Date: Aug 28, 2013 / Accepted Date: Sep 23, 2013 / Published Date: Oct 04, 2013
Abstract
In-silico modeling is increasingly being used for simulation of adsorption, distribution, metabolization, and excretion to predict the curve of plasma levels and bioavailabilityof oral drug formulations. Computational models for the prediction of other application routes are less common. Preliminary data shows that GastroPlusTM simulation software appears suitable for prediction of drug plasma levels of inhaled drugs in healthy individuals. Since also the influence of physiological variations on lung deposition can be simulated, this software could be a valuable tool in the screening of promising formulations.
Keywords: In-silico modeling; Gastroplus™; Budesonide; Turbohaler
Citation: Shengqian Wu, Salar-Behzadi S, Fröhlich E (2013) Role of In-silico modeling in Drug Development for Inhalation Treatment. J Mol Pharm Org Process Res 1: 106. Doi: 10.4172/2329-9053.1000106
Copyright: ©2013 Shengqian Wu, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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