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Role of IL6 and TNFÎñ in Hippocampal Neurogenesis of TAM Triple Knockout Mice
Lingbin Meng1, Xin Jiang2 and Rui Ji3*1Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY4020, USA
2Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, 130021, China
3Department of Biochemistry and Molecular biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
- *Corresponding Author:
- Dr. Rui Ji
University of Louisville School of Medicine
319 Abraham Flexner Way, Louisville, KY 40202, USA
E-mail: r0ji0001@louisville.edu
Received date: June 03, 2014; Accepted date: June 10, 2014; Published date: June 19, 2014
Citation: Lingbin Meng, Xin Jiang, Rui Ji (2014) Role of IL6 and TNFα in Hippocampal Neurogenesis of TAM Triple Knockout Mice. Int J Adv Innovat Thoughts Ideas 3:155. doi:10.4172/2277-1891.1000155
Copyright: © 2014 Lingbin M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
IL6 and TNFα are two main proinflammatory factors in brain. Both of them are found to play an important role in neurogenesis. However, in a chronic inflammatory disease model, TAM triple knockout mice, severe loss of neurogenesis is observed and this reduction is found to be only relevant to IL6 instead of TNFα. This finding indicates IL6 could be a promising target for treatment of some neurodegenerative diseases which are accompanied with severe neuroinflammation.
