Abstract

In colorectal cancer, fibroblast growth factor 14 (FGF14) was selectively methylated (CRC). In this work, we sought to elucidate the biological action, molecular mechanism, and epigenetic control of FGF14 in CRC. By using PCR and Western blot, the expression of FGF14 in CRC cell lines, normal human colon epithelial cell lines, CRC tissues, and matched neighbouring normal tissues was found. FGF14 blocked the PI3K/AKT/mTOR pathway and caused mitochondrial death. In conclusion, FGF14 is a new tumour suppressor that activates the PI3K/AKT/mTOR pathway to mediate cell death and restrict cell growth.