ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Case Report   
  • J Clin Exp Pathol 2015, Vol 5(6): 257
  • DOI: 10.4172/2161-0681.1000257

Retrovirus Pseudomembranous Atrophic Enteritis caused by Suicidal Emperipolesis; A Light and Ultrastructural Study

Richard E Slavin1*, John Swedo BS2 and Julie Wen MS2
1Emeritus professor, of pathology, University of Texas Medical Branch, Legacy Research Institute and Department of Pathology, Legacy Emanuel Hospital and Health Center, Portland, OR, USA
2Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA
*Corresponding Author : Richard E Slavin, Department of Pathology, Legacy Emanuel Hospital and Health Center, 2801 North Gantenbein Avenue, Portland, OR, 97227, USA, Tel: +15034134091, Fax: 150341329, Email: rslavin@lhs.org

Received Date: Sep 22, 2015 / Accepted Date: Nov 11, 2015 / Published Date: Nov 13, 2015

Abstract

Benign retroviral infections are common but are usually not recognized. This histologic and ultrastructural study identifies such an infection that became clinically evident in the small bowel following a partial colectomy for multiple micro invasive adenomas. Suspected is a low-grade retroviral infection of myeloid progenitor cells activated by inflammatory cytokines released by the operative procedure. Multiple infected neutrophils migrated to the small bowel adjacent to the operative anastomosis and through emperipolesis entered the luminal facing enterocytes. Budding of the retrovirus beginning at the neutrophil cell membrane within enterocytes assembled an immature retrovirus virus lacking a central core because translational and transcriptional viral events were not possible in the organelle poor and nuclear damaged neutrophils. Apoptosis of the infected neutrophil released toxic products and water produced in the mitochondria that distended the vacuoles encircling the neutrophils. There disruption spilled these contents directly into enterocyte cytoplasm producing collateral organelle injury that killed and detached surface enterocytes. This effaced the intestinal villi to produce atrophic and pseudomembranous enteritis with ulcers and bowel perforations.

Conclusion: The incomplete assembly of retrovirus in neutrophils rendered the virus non-infective but suicidal emperipolesis in neutrophils assembling retrovirus grouped in enterocytes created the collateral damage that caused the enteritis. This article is the first to report this suicidal variant of emperipolesis and its causative retroviral enteritis.

Keywords: Apoptosis neutrophil; Emperipolesis suicidal; Pseudomembranous enteritis; Retrovirus

Citation: Slavin RE, John Swedo BS, Julie Wen MS (2015) Retrovirus Pseudomembranous Atrophic Enteritis caused by Suicidal Emperipolesis; A Light and Ultrastructural Study . J Clin Exp Pathol 5:257. Doi: 10.4172/2161-0681.1000257

Copyright: © 2015, Slavin RE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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