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  • Research Article   
  • Arch Sci,
  • DOI: 10.4172/SCIENCE.1000127

Resveratrol-Mediated Protection via Hypoxia-Inducible Factor

Hossein Rafiei*
Department of Biology, Islamic Azad University, Shiraz, Iran
*Corresponding Author : Hossein Rafiei, Department of Biology, Islamic Azad University, Shiraz, Iran, Tel: 4917659127085, Email: hosraf1@gmail.com

Received Date: Jun 30, 2022 / Published Date: Sep 05, 2022

Abstract

Hypoxia Inducible Factor (HIF) is a dimeric protein complex that involves the body's response to hypoxia or low oxygen concentrations. The HIF pathway is induced due to insufficiency in oxygen supply into cells and tissues. It has been proposed that HIF signalling pathway contributes to the development of pathological conditions, particularly cancer. Therefore, there have been attempts to target HIF signalling pathway to inhibit the development of pathological conditions. Plant derived chemicals have shown a promising profile due to their common side effects and significant pharmacological effects. Resveratrol is a naturally occurring polyphenol exclusively found in plants such as grapes and peanuts. Resveratrol has a variety of biological and therapeutic activities, including antioxidant, anti-inflammatory, hepatoprotective, cardioprotective, anti-tumor and anti-diabetic. In the present review, we focus on the modulatory effect of resveratrol on the HIF pathway and its relationship with its protective and anti-tumor effects.

Keywords: Cancer therapy, Herbal medicine, Hypoxia inducible factor, Resveratrol

Citation: Rafiei H (2022) Resveratrol-Mediated Protection via Hypoxia-Inducible Factor. Arch Sci 6: 138. Doi: 10.4172/SCIENCE.1000127

Copyright: © 2022 Rafiei H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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