Repetitive Brain Trauma and CTE: Insights into the Pathophysiology and Long-Term Effects of Tau Accumulation
Received Date: Jul 01, 2024 / Published Date: Jul 30, 2024
Abstract
Chronic Traumatic Encephalopathy (CTE) is a progressive neurodegenerative disorder linked to repetitive brain trauma, commonly observed in athletes and military veterans. This review provides an in-depth analysis of the pathophysiological mechanisms underlying CTE, focusing on the role of tau protein accumulation. Repetitive brain injuries induce a cascade of neurobiological changes, leading to tau hyperphosphorylation and aggregation. These tau deposits, characterized by neurofibrillary tangles, contribute to widespread neuronal dysfunction and loss. The review examines the temporal progression of tau pathology, correlating it with clinical manifestations such as cognitive decline, mood disorders, and motor impairments. Emerging research highlights the complex interplay between tau pathology and other neurodegenerative processes, including inflammation and oxidative stress. Understanding the mechanisms of tau accumulation and its long-term effects is crucial for developing effective diagnostic and therapeutic strategies for CTE. This synthesis of current knowledge aims to inform future research directions and enhance our approach to managing and preventing CTE.
Citation: Abdullah M (2024) Repetitive Brain Trauma and CTE: Insights into the Pathophysiology and Long-Term Effects of Tau Accumulation J Dement 8: 226. Doi: 10.4172/dementia.1000225
Copyright: © 2024 Abdullah M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Share This Article
Recommended Conferences
42nd Global Conference on Nursing Care & Patient Safety
Toronto, CanadaRecommended Journals
Open Access Journals
Article Tools
Article Usage
- Total views: 287
- [From(publication date): 0-2024 - Feb 23, 2025]
- Breakdown by view type
- HTML page views: 233
- PDF downloads: 54