Abstract

Chronic Traumatic Encephalopathy (CTE) is a progressive neurodegenerative disorder linked to repetitive brain trauma, commonly observed in athletes and military veterans. This review provides an in-depth analysis of the pathophysiological mechanisms underlying CTE, focusing on the role of tau protein accumulation. Repetitive brain injuries induce a cascade of neurobiological changes, leading to tau hyperphosphorylation and aggregation. These tau deposits, characterized by neurofibrillary tangles, contribute to widespread neuronal dysfunction and loss. The review examines the temporal progression of tau pathology, correlating it with clinical manifestations such as cognitive decline, mood disorders, and motor impairments. Emerging research highlights the complex interplay between tau pathology and other neurodegenerative processes, including inflammation and oxidative stress. Understanding the mechanisms of tau accumulation and its long-term effects is crucial for developing effective diagnostic and therapeutic strategies for CTE. This synthesis of current knowledge aims to inform future research directions and enhance our approach to managing and preventing CTE.