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Diagnostic Pathology: Open Access
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  • Research Article   
  • Diagn Pathol Open S8: 031,

Repeated Exposure to Ozone Produces Changes in Metabolic Disturbances Present in the TDP-43A315T Transgenic Model of Amyotrophic Lateral Sclerosis

Ana Rodriguez1, Agueda Ferrer-Donato2, Susana Sesena1, Paloma Fernández3, Alfonso Aranda4 and Carmen M. Fernandez-Martos2,5*
1Department of Environmental Sciences and Biochemistry, University of Castilla-La Mancha (UCLM), Toledo, Spain
2Research Unit of the National Hospital of Paraplegics (UDI-HNP), Toledo, Spain
3 Department of Medicine, Institute of Applied Molecular Medicine (IMMA), Universidad San Pablo CEU, Madrid, Spain
4Department of Chemical Science and Technology, University of Castilla-La Mancha, Avd. Camilo José Cela, s/n Ciudad Real, Spain
5Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia
*Corresponding Author : Carmen M. Fernandez-Martos, Research Unit of the National Hospital of Paraplegics (UDI-HNP), Toledo, Spain, Tel: +34 925247789, Email: cmfernandezm@sescam.jccm.es

Received Date: Oct 19, 2021 / Accepted Date: Nov 02, 2021 / Published Date: Nov 09, 2021

Abstract

Metabolic abnormalities play a key role in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Different drugs have been used in the clinical practice; however, no current therapeutic disease-modifying intervention exists. The biological effect of ozone (O3) has gained much attention in neurodegenerative disorders, due to its strong capacity to induce controlled oxidative stress and inflammation. However, its effect on metabolism are very less studied, even though O3 is known for cause endocrine and metabolic changes, increasing food intake and body fat mass. Considering that body weight gain and mild obesity appears to improve survival in ALS patients, the aim of this study was to address the role of O3 on the metabolic disturbances present in ALS. To test this hypothesis,(4 hours/day). The effect of O3 exposure on ALS disease progression was addressed by monitoring body weight loss and motor performance until the disease end-stage in ALS mice. Furthermore, we investigated the action of O3 on plasma glucose content and biomarkers of metabolism by immunoassay. O3 exposure significantly improves motor performance and mitigates disease-associated weight loss in TDP-43A315T mice. As well, circulating levels of TDP-43TDP-43A315T mice and age-matched WT ittermates, were exposed to O3 (0.25 ppm) or filtered air (FA) for 15 days metabolic proteins and glucose in plasma were highest at disease end-stage after O exposure in TDP-43A315T mice. These findings provide the first insights into the mechanistic link between O3 exposure and the improvement of the metabolic disturbances present in ALS, based on experimental data.

Keywords: Metabolic disturbances; Pathogenesis; Biomarkers; Neurodegenerative disorders

Citation: Rodriguez A , Donato AF, Seseña S, Fernández P, Aranda A, et al. (2021) Repeated Exposure to Ozone Produces Changes in Metabolic Disturbances Present in the TDP-43A315T Transgenic Model of Amyotrophic Lateral Sclerosis. Diagnos Pathol Open S8 :031.

Copyright: © 2021 Rodriguez A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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